Endocrine Abstracts

Several papers show that maternal malnutrition can affect the reproductive capability of the offspring. Leptin is an important regulator of the reproductive system, however little is known about its role in the epididymis. The goal of this study was to evaluate whether the maternal malnutrition during lactation can alter the expression of leptin and its receptors in the epididymis of rats. Six rat dams were randomly assigned to the control group (C), with free access to a stan...

Objectives: To evaluate changes in gonadotrophins, total (TT) and free (FT) testosterone, SHBG, insulin and c-peptide levels during weight lost after bariatric surgery.Material and methods: Seven (n=7) patients submitted to bariatric surgery for treatment of severe obesity were followed-up over time. Before surgery mean age was 32,857 (19-56) years old, mean weight was 170,571 kg (± 37,362) and mean BMI was 58,824 kg per m2(± 14,...

The association of hyperandrogenism and insulin resistance is common in several syndromes. The proposed mechanism is the stimulation of ovarian theca cells by insulin to produce testosterone. Weight loss, improves insulin resistance, reduces insulin levels and consequently decreases circulating androgens.Material and methods:Ten female subjects with severe obesity and hyperandrogenism were evaluated before and after weight loss at...